There is no research on the effects of these medications on polygraph outcomes. However, if a polygraph operator were to look up these medications using the "Drug Reference" prepared by Catherine B. Onuoha, Ph.D., Research Specialist and Lecturer, Neuroscience Consultants, LLC and bundled with the Lafayette Instrument Company's LX polygraph software, he would find the information indicated in the attached two PDF files.

What the Drug Reference indicates is that cyclobenzaprine causes a minor reduction in cardio (and possibly electrodermal) responses, and that Cymbalta has no effect on the physiological indices measured by the polygraph.